Biochem/physiol Actions

Primary Target→₂-adrenoceptor

General description

A potent and selective β₂-adrenoceptor agonist (EC₅₀ = 5.3 nM) that displays bronchodilator actions. Unlike other β₂- adrenoceptor agonists, Salmeterol binds to exo-site domain of β₂-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD).

A potent and selective ?₂-adrenoceptor agonist (EC50 = 5.3 nM) that displays bronchodilator actions. Unlike other ?₂- adrenoceptor agonists, Salmeterol binds to exo-site domain of ?₂-AR receptors, producing a slow onset of action and prolonged activation. Clinically used for the treatment of asthma and chronic obstructive pulmonary disease(COPD).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Roberts, J., et al. 1999. Eur. Respir. J.14, 275.Rennard, S., et al. 2001. Am. J. Respir. Crit. Care Med.163, 1087.Akabane, H., et al. 2006. Allergol. Int.55, 387.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)